bronchiolitis/pneumonia Respiratory syncytial virus lower respiratory tract infection
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: *Age
Exclusion criteria
Exclusion criteria: *Age * 12 months *Infants born after a gestation * 32 weeks *Infants with chronic lung disease of prematurity (defined by oxygen dependency between 28 and 56 days after birth) *Infants with a haemodynamically significant congenital heart disorder *Infants with an immunodeficiency *Infants with a congenital or acquired neuromuscular disorder *Infants managed only in the outpatient department *Infants with a nosocomial (i.e. hospital acquired) RSV LRTD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in pulmonary function (i.e. airway resistance), one year after hospitalisation for RSV LRTD between mechanically ventilated and non-ventilated infants | — |
Secondary
| Measure | Time frame |
|---|---|
| *Differences in and time course of clinical, virological and immunological characteristics and markers for lung injury between mechanically ventilated and non-ventilated infants *Differences in frequency of recurrent wheezing during the first year following hospitalisation for RSV LRTD between mechanically ventilated infants and non-ventilated infants. Recurrent wheezing is defined by at least one episode of parental reported wheezing (i.e. two or more consecutive days with wheeze) *The frequency of recurrent wheezing in relation to impaired pulmonary function (i.e. airway resistance) | — |
Countries
Netherlands
Outcome results
None listed