niet van toepassing not applicable
Conditions
Interventions
During the intake session, participants will become accustomed to the sensation
of cTBS. During the following three experimental sessions, each participant
will receive continuous theta-burst stimul
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy, right handed participants (males and females) age 18-35 years. All participants will have normal or corrected to normal vision.
Exclusion criteria
Exclusion criteria: Contra-indications for TMS and fMRI: drug abuse, head trauma, neurological or psychiatric illness, pregnancy, heart disease, claustrophobia, cardiac pacemakers, metal objects in the body, medication pumps, tricyclic antidepressants, neuroleptics and a family history of neurological illness, psychiatric illness or epilepsy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reaction times, error rates and brain activity (fMRI BOLD response) will be used to test whether cTBS over the OFC, dlPFC, and PMC will uniquely affect performance on the (interaction between) 3 components of the task and whether the BOLD response is altered in the VS, CN, or putamen, respectively and the interaction between the striatal regions. | — |
Secondary
| Measure | Time frame |
|---|---|
| In order to assess functional connectivity patterns between the striatal and cortical areas, we will obtain resting state scans before and after cTBS intervention. We aim to test whether the cTBS effects are confined to those cortico-striatal loops predicted to be affected on the basis of known anatomy in non-human primates. Furthermore, this will enable us to investigate whether cTBS influences cortico-striatal circuits only when those circuits are taxed by a particular task, or whether those effects influence the ongoing pattern of functional connectivity in the cortico-striatal system, irrespective of task performance. | — |
Countries
Netherlands
Outcome results
None listed