Activation and apoptosis of peripheral T cells in relation to liver fibrosis

Activation and apoptosis of peripheral T cells in relation to liver fibrosis - Acatlife

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36633

Enrollment

140

Registered

2010-05-21

Start date

2010-09-21

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver fibrosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: One of the following chronic liver diseases: - chronic hepatitis B - chronic hepatitis C with or without treated HIV - Non-alcoholic fatty liver disease (NAFLD) - Primary Biliary Cirrosis (PBC) - HIV-positive Age >16yrs

Exclusion criteria

Exclusion criteria: -Pregnant -Other chronic liverdisease -Other disorder interfering with T cel activity or apoptosis -Alcohol intake >30g/day; substance abuse of cocaine or intravenous drugs.

Design outcomes

Primary

Measure	Time frame
a number of immunological markers will be evaluated on all subjects and controls. Markers to be investigated are T cell surface markers of proliferation, differentiation, activation, homing and apoptosis, intracellular markers of activation and cell death and serum markers of apoptosis.	—

Secondary

Measure	Time frame
The level of fibrosis and various underlying hepatic diseases are secundary study parameters, together with certain markers of T cell activation and apoptosis.	—

Countries

Netherlands

Outcome results