Identifying markers for response to cardiac resynchronization therapy in the Maastricht University Medical Centre; a prospective follow-up study

Identifying markers for response to cardiac resynchronization therapy in the Maastricht University Medical Centre; a prospective follow-up study - IMAR-CRT study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36624

Enrollment

100

Registered

2011-02-16

Start date

2011-02-21

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure and left bundle branch block

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria are: * Indication for CRT (made by the cardiologist independently of the study) * Age >18 years * Capable of giving informed consent

Exclusion criteria

Exclusion criteria: Exclusion criteria are: * Any known condition that could limit life expectancy

Design outcomes

Primary

Measure	Time frame
- Prediction by the new composite algorithm of the degree of response on CRT, defined as %decrease in LVESV at 6 months	—

Secondary

Measure	Time frame
- Additional improvement in prediction of the degree of response by exploring secondary potential markers for response to CRT - Prediction by the new composite algorithm of the degree of response on CRT, defined as %increase in LV ejection fraction (LVEF) points at 6 months - Change in ECG and three-dimensional vectorcardiography (VCG) at 6 months of CRT - Changes in NT-pro-BNP and other known and future biomarkers levels at 6 months of CRT - Change in NYHA functional class at 6 months of CRT - Change in Quality of Life scores assessed by means of the Minnesota Living with Heart Failure Questionnaire and EuroQol at 6 months of CRT - Change in the six minutes hall walk test (6MWT) at 6 months of CRT - Repolarization changes obtained with 3-dimensional VCG at 1, 5, 10 days, 1, 3 and 6 months of CRT - Changes in echocardiographic parameters of diastolic heart function as well as heterogeneity in time to peak longitudinal strains at 1, 5, 10 days, 1, 3 and 6 months of CRT - Occurrence of arrhythmias at 1, 5, 10 days, 1, 3 and 6 months of CRT	—

Measure

Time frame

- Additional improvement in prediction of the degree of response by exploring secondary potential markers for response to CRT - Prediction by the new composite algorithm of the degree of response on CRT, defined as %increase in LV ejection fraction (LVEF) points at 6 months - Change in ECG and three-dimensional vectorcardiography (VCG) at 6 months of CRT - Changes in NT-pro-BNP and other known and future biomarkers levels at 6 months of CRT - Change in NYHA functional class at 6 months of CRT - Change in Quality of Life scores assessed by means of the *Minnesota Living with Heart Failure Questionnaire* and EuroQol at 6 months of CRT - Change in the six minutes hall walk test (6MWT) at 6 months of CRT - Repolarization changes obtained with 3-dimensional VCG at 1, 5, 10 days, 1, 3 and 6 months of CRT - Changes in echocardiographic parameters of diastolic heart function as well as heterogeneity in time to peak longitudinal strains at 1, 5, 10 days, 1, 3 and 6 months of CRT - Occurrence of arrhythmias at 1, 5, 10 days, 1, 3 and 6 months of CRT

—

Countries

Netherlands

Outcome results