diabetes
Conditions
Interventions
The first scan will be performed following a hyperinsulinaemic normoglycaemic
clamp and the second scan will be performed following a hyperinsulinaemic
hypoglycaemic clamp (separated from the first
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for healthy volunteers * Male * Caucasian race * 18-50 years old * BMI 20-28 kg/ m2 * Subjects should be able and willing to give informed consent;Inclusion criteria for type 1 diabetes patients * Male * Caucasian race * Age 18-50 years * BMI 20-28 kg/ m2 * Type 1 Diabetes Mellitus * Subjects should be able and willing to give informed consent
Exclusion criteria
Exclusion criteria: Exclusion criteria for healthy volunteers * Use of prescription medications (beta-adrenoreceptor blockers) * Cardiac history (previous arrhythmia) * History of epilepsy * Acute illness within 3 months before the study * Significant renal impairment (creatinine clearance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Standardised Uptake Value (SUV) of the tracer [18F]-fluorodeoxyglucose (FDG) visualised with positron emission tomography (PET) in BAT (normoglycaemia vs. hypoglycaemia). | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference between the change in SUV in BAT in the group with healthy volunteers versus the diabetes patients. | — |
Countries
Netherlands
Outcome results
None listed