Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? Presence of Anti Citrullinated Protein Antibodies (ACPAs) in periodontitis.

Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? Presence of Anti Citrullinated Protein Antibodies (ACPAs) in periodontitis. - ACPAs in periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36598

Enrollment

Registered

2011-02-17

Start date

2010-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gum disease periodontal disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Fulfilling the classification criteria of periodontal diseases for generalized severe periodontitis according to the 1999 International Workshop for Classification of Periodontal Diseases and Conditions 2. Age > 18 years

Exclusion criteria

Exclusion criteria: According to the SENIEUR protocol (1984) 1. Infection or inflammation other than periodontitis. 2. Malignancy, past or present 3. Other conditions which influence the immune system: RA, diabetes, active thyroid disease myocardial infarction, stroke or recanalisation of the femoral arteries for claudication 10mg/day, antibiotic use during 3 months prior to the study 8. Edentulism

Design outcomes

Primary

Measure	Time frame
ACPA titer	—

Secondary

Measure	Time frame
Periodontal inflamed surface area (PISA), presence of P. gingivalis, and development of clinical symptoms of RA.	—

Countries

Netherlands

Outcome results