Effects of exercise on the immune system in pediatric acute lymphoblastic leukemia (ALL) patients.

Effects of exercise on the immune system in pediatric acute lymphoblastic leukemia (ALL) patients. - Exercise and Immunology in ALL (ExImA)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON36567

Enrollment

Registered

2010-03-11

Start date

2011-02-25

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer of the blood

Interventions

Three different bouts of exercise: cycle ergometer test, active computer game and physical therapy session

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: •Diagnosis of Acute lymphoblastic leukemia (ALL) with a port-a-cath - medium risk, based on DCOG ALL 10 protocol. •Sufficiently healthy to participate •A minimal body mass of 25 kg will be required, in order to allow repeated blood sampling

Exclusion criteria

Exclusion criteria: •Down syndrome or children with multiple morbidity •Non-ambulation: patients who are unable to ambulate or who will not be able to complete any part of the study protocol due to the severe physical limitations will be excluded •Unable to cooperate with testing procedures (e.g. insufficient understanding of Dutch language)

Design outcomes

Primary

Measure	Time frame
The main study parameter is the change in inflammatory markers before and after different bouts of exercise.	—

Secondary

Measure	Time frame
Correlation between exercise-induced change in inflammatory markers and physical fitness (VO2peak) • Correlation between changes in inflammatory markers (e.g NK cells, IL-6, IL-8, IL-10, C-reactive protein and TNF-a) and neutrophil function. • Difference in enjoyment between the 3 different exercise training sessions	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)