Diverticular disease diverticulosis
Conditions
Interventions
None listed
Sponsors
Kennemer Gasthuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Eighteen years or older; • Scheduled for colonoscopy for: 1. Hematochezia; 2. gastrointestinal hemorrhage; 3. unexplained changes in bowel habit; 4. weight loss; 5. iron-deficiency anemia; 6. chronic obstipation without positive reaction on the treatment; 7. screening for and follow-up of colorectal cancer;
Exclusion criteria
Exclusion criteria: • Suspicion of diverticular related complaints; • Proven history of symptomatic diverticular disease; • Use of coumarin derivates, unless stopped one week before colonoscopy; • Use of NSAID*s unless stopped one week before colonoscopy; • Use of platelet aggregate inhibitors, including aspirin, unless stopped one week before colonoscopy; • Sedation before informed consent; • History of inflammatory bowel disease; • Endoscopic signs of inflammation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammation, defined as mean T lymphocyte count and neutrophil count in the mucosa of the colon. | — |
Secondary
| Measure | Time frame |
|---|---|
| Colonic flora, expressed as anaerobic/ aerobic ratio and presence or absence of certain strains of bacteria by means of micro-array. | — |
Countries
Netherlands
Outcome results
None listed