Investigation of cerebrovenous haemodynamics by transcranial and extracranial Color-Doppler sonography and MR-venography in patients with multiple sclerosis and healthy controls.

Investigation of cerebrovenous haemodynamics by transcranial and extracranial Color-Doppler sonography and MR-venography in patients with multiple sclerosis and healthy controls. - Cerebral venous drainage in MS patients and controls

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36557

Enrollment

220

Registered

2011-01-18

Start date

2011-01-20

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inflammatory disease of the central nervous system multiple sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: a. Patients affected by clinical defined MS, diagnosed according to the McDonald criteria. Relapsing-remitting MS, secondary-progressive MS, primary-progressive MS. b. Age > 18 years and less than 65 years.

Exclusion criteria

Exclusion criteria: a. We exclude from the study those subjects having, or showing the potential for developing, a nervous system pathology of a venous refluxive and/or obstructive nature, including:;1. Chronic venous insufficiency of the lower limbs 2. History of venous thrombosis and/or post-thrombotic syndrome 3. Genetic thrombophilia 4. Congenital angiodysplasias 5. Congenital vascular malformations 6. Budd-Chiari syndrome 7. Behcet disease 8. Other vasculitis;b. An acute relapse and/or steroid treatment within the 30 days preceding study entry c. CIS patients (clinically isolated symptoms), that is patients with the first episode fitting with central demyelination.

Design outcomes

Primary

Measure	Time frame
Presence of two or more of the five parameters of impaired cerebral venous drainage as seen in chronic cerebrospinal venous insufficiency in MS patients and healthy controls is the main study parameter.	—

Secondary

Measure	Time frame
Secondary parameters: prevalence of chronic cerebrospinal venous insufficiency in MS patients and healthy controls.	—

Countries

Netherlands

Outcome results