Diffuse Optical Tomography (DOT) and Magnetic Resonance Imaging (MRI) image fusion, development of methods in volunteers and validation in patients with benign cysts of the breast

Diffuse Optical Tomography (DOT) and Magnetic Resonance Imaging (MRI) image fusion, development of methods in volunteers and validation in patients with benign cysts of the breast - fusion of MRI and DOT images

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36530

Enrollment

Registered

2011-03-23

Start date

2011-06-23

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cysts cysts of the breast

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Females age 18 years old or over , given written informed consent Group A (volunteers): No known breast lesion Group B (patients with benign cysts): Ultrasound proven benign cyst (BI-RADS 2)

Exclusion criteria

Exclusion criteria: - Recent (surgical) interventions (including cytology, surgery) of the breast - Piercings or tattoos on the breast - Breast located skin disease - Group B: cyst located close to the chest wall

Design outcomes

Primary

Measure	Time frame
Part A aims at adapting and fine-tuning the fusion methods developed with breast phantoms. In part B, the adapted methods will be validated using imaging data of 15 patients with benign cysts. Target Registration Errors (TRE, displacement vectors) will be calculated and should not exceed two voxels of the corresponding spatial resolution on the DOT images.	—

Secondary

Measure	Time frame
Secondary objectives include the training of personnel in handling patients on the PMS-DOT prototype in order to streamline current and upcoming studies (part A). Also, the features of two available optical matching fluids will be investigated.	—

Countries

Netherlands

Outcome results