psychosis schizophrenia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: This is a follow-up study. Inclusion criteria will be the same as initial intake. General inclusion criteria: - For subjects who initially participated in the DUPS study: Age between 12 and 18 years at initial inclusion - For new subjects: Aged between 12 and 24 years at initial inclusion (to allow us to supplement the DUPS sample) Inclusion criteria for Ultra High Risk for Psychosis (UHR) Group: - No previous psychotic episode for more than one week - No clear organic etiological factor - Voluntary participation (informed consent) - Meets criteria for UHRP (page 19-21 of protocol) Inclusion criteria for controls: -No history of psychiatric disorder (axis 1, DSM-IV) according to diagnostic interview (DISC or SCAN) -No history of psychotic disorder in first or second-degree family members
Exclusion criteria
Exclusion criteria: -Mental retardation (IQ
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measures are: (1) Cortical thickness, as assessed using a standard anatomical MRI scan (3D-FFE) (2) White matter integrity, as assessed using track-based FA measures from DTI | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures are: (1) Volume of brain structures, as assessed using a standard anatomical MRI scan (3D-FFE) (2) Connectivity of resting state networks, as assessed with resting state fMRI (3) Genotype on candidate risk genes for psychosis | — |
Countries
Netherlands
Outcome results
None listed