Laser Speckle Imaging of blood flow in the microcirculation of the cerebral cortex

Laser Speckle Imaging of blood flow in the microcirculation of the cerebral cortex - Laser Speckle Imaging of cerbral cortex

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36491

Enrollment

Registered

2011-02-11

Start date

2013-08-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

function of the microcirculation in the cerebral cortex

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All patients that will undergo an awake craniotomy will be eligible for protocol A. They have to be at least 18 years old and there has to be informed consent. All patients that will undergo a craniotomy under anaesthesia are eligible for protocol B. They have to be at least 18 years old and there has to be informed consent.

Exclusion criteria

Exclusion criteria: -

Design outcomes

Primary

Measure	Time frame
The aim of the study is two-sided. First we propose to investigate and further develop the use of LSI to asses blood flow changes coupled to neuronal activities and to find out whether this approach can be used during tumor dissection. Secondly we aim to investigate the effects of several therapeutic standard interventions (infusion of mannitol, artificial elevation of mean arterial pressure and placement of surgical devices), which are expected to influence CBF, and are routinely used during neurosurgical procedures on microcirculatory flow in the brain, with and without the use of Transcranial Doppler Ultrasound to compare blood flow velocity in the microvasculature with the larger cerebral arteries.	—

Measure

Time frame

The aim of the study is two-sided. First we propose to investigate and further develop the use of LSI to asses blood flow changes coupled to neuronal activities and to find out whether this approach can be used during tumor dissection. Secondly we aim to investigate the effects of several therapeutic standard interventions (infusion of mannitol, artificial elevation of mean arterial pressure and placement of surgical devices), which are expected to influence CBF, and are routinely used during neurosurgical procedures on microcirculatory flow in the brain, with and without the use of Transcranial Doppler Ultrasound to compare blood flow velocity in the microvasculature with the larger cerebral arteries.

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Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results