Endocrine profile of PerIcoronary adipose tissue in relation to Coronary ARtery Disease study

Endocrine profile of PerIcoronary adipose tissue in relation to Coronary ARtery Disease study - EPICARD study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36488

Enrollment

Registered

2009-09-22

Start date

2009-12-03

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerosis coronary artery disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria 1. Written and signed informed consent. 2. Male or female patients. 3. Scheduled for elective CABG. 4. >= 50% stenosis of the RCA, LAD, diagonal branche of the LAD (DIAG) or mo branches of the RCx.

Exclusion criteria

Exclusion criteria: Exclusion criteria 1. Thyroid disease (TSH 5.0 mU/L or use of thyroid hormones) 2. History of malignancy (in the last 2 years) 3. Use of thiazolidinediones 4. Use of immune suppressive medication (equivalent of prednisolon >= 10 mg /day) 5. Renal failure GFR

Design outcomes

Primary

Measure	Time frame
onderzoeksvariabelen: - Adipokine en cytokine mRNA expression (RT-PCR) and secretion (Western blotting): adiponectin, IL-6, TNF-a, resistin, PAI-1 en visfatin - Histologic parameters of inflammation: macrophage infiltration (macrophages per view), capillary injection (capillaries per view) en fat necrosis (presence of) . outcome measures: - Stenosis (atherosclerotic plaque) measured with coronary angiography.	—

Measure

Time frame

onderzoeksvariabelen: - Adipokine en cytokine mRNA expression (RT-PCR) and secretion (Western blotting): adiponectin, IL-6, TNF-a, resistin, PAI-1 en visfatin - Histologic parameters of inflammation: macrophage infiltration (macrophages per view), capillary injection (capillaries per view) en fat necrosis (presence of) . outcome measures: - Stenosis (atherosclerotic plaque) measured with coronary angiography.

—

Secondary

Measure	Time frame
- Plasma adipokine and cytokine concentrations (adiponectine, IL-6, TNF-a, resistin, PAI-1 en visfatin) - Parameters of the metabolic syndrome (waist circumference (cm), LDL-c, HDL-c, total cholesterol, fasting glucose, blood pressure) - Adipocyte size	—

Countries

Netherlands

Outcome results