Visualizing differences in cerebral dopamine- and serotonin transporters between lean subjects and obese subjects with normal- and decreased insulin sensitivity

Visualizing differences in cerebral dopamine- and serotonin transporters between lean subjects and obese subjects with normal- and decreased insulin sensitivity - Brain Imaging in Obesity

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36484

Enrollment

Registered

2011-07-29

Start date

2011-01-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glucose intolerance insulin resistance

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: BMI > 30 kg/m2, age 18-40 years, Caucasian

Exclusion criteria

Exclusion criteria: DM with need of therapy (insulin or oral therapy); use of any medication; renal insufficiency (kreat > 150 µmol/L; elevated liver enzymes (>2x above the upper limit of normal); hypothyroidism; intoxications (alcohol- (>3/day), ecstasy-, amphetamine- or cocaine abuse), smoking; shift work

Design outcomes

Primary

Measure	Time frame
Difference in cerebral binding of the radioligand [123I]FP-CIT to serotonin- and dopamine transporters between obese subjects and healthy volunteers and between obese subjects with- and without insulin resistance.	—

Secondary

Measure	Time frame
Correlation between binding of the radioligand [123I]FP-CIT to cerebral serotonin- and dopamine transporters and: 1. amount of fat 2. glucoregulatory hormones in plasma 3. appetite regulating peptides in plasma	—

Countries

Netherlands

Outcome results