MR Imaging of cerebral blood flow and autoregulation in patients with steno-occlusive vertebro-basilar artery disease.

MR Imaging of cerebral blood flow and autoregulation in patients with steno-occlusive vertebro-basilar artery disease. - VICTOR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36475

Enrollment

Registered

2011-05-02

Start date

2012-09-14

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischaemic cerebral stroke

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 18 years or older. Patients with ischaemic stroke or TIA in the perfusion territory of the vertebo-basilar arteries. In case of stroke: a clinically stable situation.

Exclusion criteria

Exclusion criteria: Significant and symptomatic stenosis of the carotid arteries. Pregnancy or possible pregnancy. Implanted stent(s). Severe liver or renal dysfunction. Addison*s disease. Allergic reaction for sulfonamides. Cor pulmonale / heart failure (class III-IV) according to the NYHA classification. Longobstruction / emfysema. Primary hyperaldosteronisme. Fenytoïne, primidon and/or fenobarbital use. Japanese and Indian subjects or subjects of Japanese descent. Impossibility to undergo MRI (claustrophobia, metal objects in or around the body).

Design outcomes

Primary

Measure	Time frame
The primary outcome is CVR measured with MR imaging at 3 Tesla using administration of vasodilatory challenge medication to induce hemodynamic stress.	—

Secondary

Measure	Time frame
Secondary outcomes include cerebral blood flow (CBF) and CVR measured in the visual cortex, and differences in CBF and CVR between the recently symptomatic and asymptomatic patients.	—

Countries

Netherlands

Outcome results