Coronary Artery Plaque Characterisation with Non-invasive Multi-Slice Computed Tomography and Invasive Intravascular Ultrasound and Optical Coherence Tomography in Patients with Acute Coronary Syndromes Without ST-segment Elevation

Coronary Artery Plaque Characterisation with Non-invasive Multi-Slice Computed Tomography and Invasive Intravascular Ultrasound and Optical Coherence Tomography in Patients with Acute Coronary Syndromes Without ST-segment Elevation - Non-invasive and invasive plaque characterisation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON36442

Enrollment

Registered

2011-04-15

Start date

2011-06-29

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerosis

Interventions

The participants will undergo extra examinations. 1) A MSCT examination preliminary of the percutaneous coronary intervention

and 2) during the percutaneous coronary intervention a IVUS and OCT examination.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Chest pain suggestive for myocardial ischemia for at least 30 minutes; - Electrocardiogram (ECG) with ST-segment shifts (ST-segment depression >1 mm in at least two contiguous leads or transient ST-segment elevation > 1mm with duration of 1.5 mm in at least three contiguous leads); - Positive hs Troponin T > 14 ng/L or positive Troponin T

Exclusion criteria

Exclusion criteria: - Persistent ST-elevation of >1 mm in 2 or more leads; - Need for emergency invasive coronary angiography and PCI; - Need for emergency coronary artery bypass grafting; - Presence of cardiogenic shock; - Estimated glomerular filtration rate (eGFR)

Design outcomes

Primary

Measure	Time frame
The accuracy of coronary plaque characterization with MSCT as compared to IVUS and OCT will be investigated. In addition, the correlation between plaque characteristics and clinical characteristics (gender and diabetes) will be explored.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)