stroke
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: patients with sickle cell disease treated at AMC aged 18-25
Exclusion criteria
Exclusion criteria: Overt stroke, defined as a focal neurological deficit with either motor or sensory deficit lasting more than 24 hr or focal neurological deficit lasting less than 24 hr with neuroimaging evidence of a cerebral infarct corresponding with the focal deficit. Chronic blood transfusion schedule. The presence of metal in the body (e.g. osteosynthetic material, pacemaker, artificial cardiac valves). Claustrophobia. Surgery performed in the area of measurement in the last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the presence of (pre-) pathological changes of brain parenchyma, blood vessels or other intracranial structures at 7.0 Tesla MRI. Intracerebral changes include cystic infarction, atrophy, encephalomalacia, leukoencephalopathy or changes of the intracerebral blood vessels. | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographical and clinical patient characteristics including age, HbS phenotype, Hb, HbF, leukocytes during stable clinical state, presence of epilepsy. Cerebral blood flow asymmetry, defined as previously described by Van den Tweel et al. Neurological examination. Verbal IQ, performance IQ and full scale IQ, and visuo-motor functioning. | — |
Countries
Netherlands
Outcome results
None listed