The Rolandic epilepsy/ESES/Landau-Kleffner Syndrome and correlation with Language impairment study

The Rolandic epilepsy/ESES/Landau-Kleffner Syndrome and correlation with Language impairment study - REL&language1

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36427

Enrollment

Registered

2010-08-09

Start date

2010-10-29

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: • Diagnosis of Rolandisch epilepsy, ESES, ESES-like or Landau-Kleffner syndrome • Age of 8 to 18 years • Clinical and electroencephalographic evidence of seizures. • Non-symptomatic epilepsy;Healthy control group Inclusion criteria for healthy control children: • Children aged 8 to 16 years • Normal intelligence/following regular schools

Exclusion criteria

Exclusion criteria: • MRI lesions on previous structural brain MRI- or CT-scans or symptomatic epilepsy (e.g. tumours, vascular abnormalities, congenital dysgenesia) • Progressive neurological disorders • Other diseases/ causes that may underlie cognitive impairment (i.e. psychiatric diseases) • Vision less than +4.5D or - 4.5D • Claustrophobia • Metal implants or other contraindication for MRI • Parents not willing to provide informed consent;Healthy control children Exclusion criteria for the healthy control children: • Medical history of head trauma or other diseases/ causes that may underlie cognitive impairment (i.e. psychiatric diseases) • Inability to speak/understand the Dutch language • Vision less than +4.5D or - 4.5D • Claustrophobia • Metal implants or other contraindication for MRI • Parents not willing to provide informed consent • Parents who do not want to get informed whenever structural abnormalities are found during imaging

Design outcomes

Primary

Measure	Time frame
Abnormalities that are related to Rolandic epilepsy, ESES-like, ESES, LKS, language impairment, cognitive impairment and/or refractoriness. Endpoints are the microstructural and functional integrity, seizure history, IQ-scores, and response to anti-epileptic drug treatment or other treatment (corticosteroids), EEG-parameters (localisation and frequency of epileptic activity). (For further information see: Methods, primary study parameters/endpoints)	—

Measure

Time frame

Abnormalities that are related to Rolandic epilepsy, ESES-like, ESES, LKS, language impairment, cognitive impairment and/or refractoriness. Endpoints are the microstructural and functional integrity, seizure history, IQ-scores, and response to anti-epileptic drug treatment or other treatment (corticosteroids), EEG-parameters (localisation and frequency of epileptic activity). (For further information see: Methods, primary study parameters/endpoints)

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Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results