Microvascular lesions in the brain in Alzheimer*s disease: identification of a novel biomarker with 7T MRI

Microvascular lesions in the brain in Alzheimer*s disease: identification of a novel biomarker with 7T MRI - Cerebral microvascular lesions in AD

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36418

Enrollment

Registered

2010-03-22

Start date

2010-06-17

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease Dementia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Participant of *parelsnoer neurodegeneratieve ziekten* project and diagnosed with (possible) Alzheimer's disease.;For parelsnoer: referred to memory clinic subjective and/or objective cognitive impairment CDR 0, 0.5 or 1 MMSE 20 or higher

Exclusion criteria

Exclusion criteria: Normal pressure Hydrocephalus, M. Huntington Recent CVA (

Design outcomes

Primary

Measure	Time frame
The prevalence and total number of microinfarcts at 7T The prevalence and total number of microbleeds at 7T For the parelsnoer project participants will already receive a full clinical assessment, neuropsychological tests and a 3T MRI. Participants in the present study will also undergo some additional neuropsychological tests and a 7T MRI.	—

Secondary

Measure	Time frame
• Conventional brain MRI markers of AD (atrophy) and vascular lesions (large infarcts, white matter hyperintensities) at 3T MRI • Cognitive profile • Vascular risk factor profile	—

Countries

Netherlands

Outcome results