verslaving cocaine addiction
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male subjects with cocaine dependence as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV; American Psychiatric Association 1994), and will be determined by a structured interview (Composite International Diagnostic Interview: CIDI) aged 18-40 years. Controls: male healthy volunteers aged 18-40 years.
Exclusion criteria
Exclusion criteria: No cocaine dependence Positive DSM-IV/CIDI for any drug other than cocaine, heroin, alcohol or marijuana Major neurological disorders, claustrophobia, peripheral vascular diseases, current use of respiratory, cardiovascular, anticonvulsant or psychoactive medications (SSRIs), or alexithymia A positive urine test result for amphetamines, barbiturates, benzodiazepine metabolites, cocaine (metabolite), opiates, alcohol, and marijuana
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Vigilance level (an fMRI task): % BOLD signal change in the ventral frontostriatal circuit (which is associated with reversal learning). - 5HTT function (a phMRI study): peak amplitude (maximum % change relative to baseline) in cerebral blood flow (CBF) evoked by an acute pharmacological challenge with citalopram. | — |
Secondary
| Measure | Time frame |
|---|---|
| none | — |
Countries
Netherlands
Outcome results
None listed