Lou Gehrig disease
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: ALS patients must fulfill not less than the revised El Escorial category for probable, laboratory supported ALS. Symptom onset, defined as onset of weakness, must be less than 14 months ago.
Exclusion criteria
Exclusion criteria: Patients with pure upper motor neuron signs or *suspected ALS* will not be eligible for the study. Any history of major neurological disorders that might influence MUNIX measurements (e.g. polyneuropathy, peripheral nerve damage, paresis of any cause, muscular atrophy) in ALS patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MUNIX inter-rater and intra-rater variability and reproducibility. Longitudinal relation of MUNIX with the revised ALS functional rating scale (ALSFRS-R). | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation CMAP and MUNIX with echointensity on baseline and after 6 and 12 months | — |
Countries
Netherlands
Outcome results
None listed