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Influence of ryanodyne receptor 1 mutations on pulmonary arterial pressure and ventilation during isocapnic hypoxia

Influence of ryanodyne receptor 1 mutations on pulmonary arterial pressure and ventilation during isocapnic hypoxia - Ryan op pad

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON36376
Enrollment
24
Registered
2011-05-23
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary hypertension

Interventions

hypoxia

Sponsors

Leids Universitair Medisch Centrum
Lead Sponsor

Eligibility

Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy Malignant Hyperthermia patients with a phenotypic high susceptibility and a proven causative mutation. The major inclusion criteria are that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.

Exclusion criteria

Exclusion criteria: • Obesity (BMI > 30) • Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes • Presence of psychiatric disease • History of chronic alcohol or drug use • Possibility of pregnancy • Lactation

Design outcomes

Primary

MeasureTime frame
HPV—

Secondary

MeasureTime frame
cardiac parameters hypoxic ventilatory response—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)