Gadobutrol (Gadovist®) versus gadofosveset-trisodium (Vasovist®) in MR venography of the peripheral venous vasculature in deep vein thrombosis: is their a need for blood pool contrast agents?

Gadobutrol (Gadovist®) versus gadofosveset-trisodium (Vasovist®) in MR venography of the peripheral venous vasculature in deep vein thrombosis: is their a need for blood pool contrast agents? - MR Venography in deep vein thrombosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36357

Enrollment

Registered

2011-06-30

Start date

2011-11-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep vein thrombosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Age between 18-65 years * Objectively documented DVT * Patient scheduled for CE-MRV * Patient able to undergo CE-MRV twice within one week * Patient is not scheduled to receive invasive treatment between both examinations

Exclusion criteria

Exclusion criteria: * Hemodynamic instability * Known allergy for gadolinium based MR contrast agents * Contra-indications for MRI * eGFR

Design outcomes

Primary

Measure	Time frame
Image quality of our current method using vasovist will be compared with image quality of the new scan sequence, both with Vasovist and Gadovist as contrast agents. Image quality will assessed both subjectively and objectively. For subjective assessment of image quality a 8-point scale is used to determine clinical suitability and influence of image artifacts. Objective assessment of image quality is performed by measuring the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).	—

Measure

Time frame

Image quality of our current method using vasovist will be compared with image quality of the new scan sequence, both with Vasovist and Gadovist as contrast agents. Image quality will assessed both subjectively and objectively. For subjective assessment of image quality a 8-point scale is used to determine clinical suitability and influence of image artifacts. Objective assessment of image quality is performed by measuring the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).

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Secondary

Measure	Time frame
Images quality of DSA images will be compared with MRV data using the same method.	—

Countries

Netherlands

Outcome results