Sex hormones, sex chromosomes, and sexual differentiation of the brain

Sex hormones, sex chromosomes, and sexual differentiation of the brain - Sex hormones, sex chromosomes, and the brain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36349

Enrollment

Registered

2010-10-11

Start date

2011-07-05

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sexual differentiation of the brain disorder of sex development testicular feminization

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All subjects: Right-handed, Normative olfactory performance,Written informed consent obtained;Healthy Volunteers: Heterosexual orientation, Sex-typical gender identity;Transsexual controls: Genetically male, sex-atypical gender identity;Patients: Diagnosis of complete androgen insensitivity syndrome (CAIS)

Exclusion criteria

Exclusion criteria: All subjects: Smoking, Excessive drug/alcohol use, Psychiatric and Neurological illness, Significant physical illness (excluding diagnosis of CAIS), Anosmia or hyposmia, MRI contraindications ;Healthy Volunteers (20 men and 20 of 40 women): Hormone therapy or birth control pills

Design outcomes

Primary

Measure	Time frame
The parameters of interest include brain morphology, the ability to detect AND, CEOAE scores, 2D:4D ratios, brain activity in the resting state as well as in response to AND presentation and two cognitive tasks during the fMRI experiment, and estrogen (estradiol and ethinylestradiol), LH, FSH, progesterone and testosterone levels on the test day.	—

Countries

Netherlands

Outcome results