HSPG Expression in non-alcoholic steato hepatitis And type II Diabetes Mellitus.

HSPG Expression in non-alcoholic steato hepatitis And type II Diabetes Mellitus. - HASTROII

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON36347

Enrollment

Registered

2011-02-08

Start date

2011-05-09

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NASH sugar disease type 2 diabetes mellitus

Interventions

Liverbiopsy during gastric bypass surgery. Venapunction. Bloodvolume will be 37,5 ml in total Feaces collection

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Caucasian males or females • Age 18 - 60 years old • Type 2 diabetes mellitus • Presence of ultrasound confirmed NASH • Undergoing gastric bypass surgery

Exclusion criteria

Exclusion criteria: • Active malignancy • Cholestasis • History of Hepatitis B/Hepatitis C

Design outcomes

Primary

Measure	Time frame
•HSPGs expression in liver tissue and gutepithelium, measured by qPCR and western blot, in insulin resistant NASH versus non-insulin resistant NASH and controls	—

Secondary

Measure	Time frame
•Association between hepatic and gut epithelium HSPGs expression and triglyceride-rich lipoproteins and FFA*s in non fasting peripheral and portal lipid samples versus feces sample. •Association between hepatic HSPGs expression and HOMA index	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)