headache
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: General Inclusion criteria: • Women • Age between 18 and 75 years • Non-smoking for > 6 months • Body mass index between 18 and 30 • Capable and willing to give informed consent • General good health, based on medical history and physical examination;Subjects with migraine: • Should have diagnosed migraine, fulfilling criteria 1.1. Migraine without aura of International Classification of Headache Disorders (ICHD). • Migraine attacks should occur exclusively on day 1±2 (ie, days -2 to +3) of menstruation in at least two out of three menstrual cycles and additionally at other times of the cycle. • Should have a natural and regular menstrual cycle • Age between 18 and 45 years;Subjects without migraine: • Should have a natural and regular menstrual cycle • Age between 18 and 45 years Postmenopausal subjects • Should be amenorrhoeic for at least 1 year
Exclusion criteria
Exclusion criteria: • Use of hormonal contraceptives or hormonal replacement therapy • History of cardiovascular disease • Any serious illness that can compromise study participation • Regular use of medication outside the period of migraine attacks • Dermal diseases at the upper frontal side of the face • Pregnancy or breastfeeding • History of sensitivity to the fruits of capsicum plants (eg chilli peppers) • Alcohol or drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in capsaicin-induced vasodilatation between women with and without migraine. Effect of estrogen en progesterone levels on the capsaicin induced vasodilatation. | — |
Countries
Netherlands
Outcome results
None listed