Voluntary motor activity in Restless Legs Syndrome and Periodic Limb Movements in Sleep

Voluntary motor activity in Restless Legs Syndrome and Periodic Limb Movements in Sleep - Motor activity in RLS and PLMS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36343

Enrollment

Registered

2011-04-14

Start date

2011-12-21

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodic Limb Movements in Sleep Restless Legs Syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Right-handed Age > 18 years RLS Patients with PLM: - fullfilling the criteria for RLS - Periodic Limb Movement Index (= PLMI) > 25 PLMS patients: - not fullfilling the criteria for RLS - PLMI > 25 Normal controls - not fullfilling the criteria for RLS - PLMI

Exclusion criteria

Exclusion criteria: - other neuropsychiatric diseases - causes of secondary PLMS such as Obstructive Sleep Apneu Syndrome, reumatoid artritis, anaemia - centrally active drugs, apart form RLS or PLMS medication - contra-indications for Transcranial Magnetic Stimulation (pregnancy, elektronic devices such as pacemaker)

Design outcomes

Primary

Measure	Time frame
Voluntary fine motor activity will be studied using a manipulandum: a joystick-like device that permits movements in the wrist. Performance (speed, position relative to the manipulandum and position relative to the task) will be compared between groups and controls. Transcranial magnetic stimulation (TMS) will be used to study sensorimotor integration and intracortical inhibition.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results