mental disorder with hallucinations and delusions psychotic disorder
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: a. Persons who have had no previous psychotic episode for more than one week and spontaneous remission. In addition, each person falls into one or more of the following groups: 1. Familial risk plus reduced functioning: leading to a reduction of 30 percent or more on the Global Assessment of Functioning (GAF) Scale. 2. Attenuated psychotic symptoms: Presence of at least one of the ultra high risk symptoms as assessed with the Structured Interview for Prodromal Symptoms (SIPS): a score between 3 and 5 on the positive symptoms indicates attenuated psychotic symptoms and a score of 6 indicates a psychotic state. age 18-30 b. patients with a recently developed psychotic disorder, age 18-30 c. participants with no family history of psychosis , age 18-30
Exclusion criteria
Exclusion criteria: exclusion criteria for controls: family history for psychosis. Psychotic symptoms due to an organic etiological factor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Trait anxiety is measured by self-rating lists STAI DY and BIS/ BAS. Sensory motor gating is measured by Pre Pulse Inhibition of the Acoustic Startle Reflex recorded by electro myograhpic recordings of the orbicularis oculi muscle through dermal electrodes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Possible influence of age, hormonal cycle in females, medication and smoking behaviour are assessed through demographic information list that participants are requested to fill in. Female hormonal influences are also measured by levels of estradiol and progestron determined from bloodsample. | — |
Countries
Netherlands
Outcome results
None listed