Abnormal sex hormone exposure of the brain; possible neuroendocrine implications for cognition in adult transsexuals and women with polycystic ovarian syndrome as clinical models

Abnormal sex hormone exposure of the brain; possible neuroendocrine implications for cognition in adult transsexuals and women with polycystic ovarian syndrome as clinical models - Sex hormones and cognition

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36332

Enrollment

100

Registered

2009-11-12

Start date

2010-06-01

Completion date

Unknown

Last updated

2024-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Geslachtsaanpassende behandeling voor genderdysforie Polycyctic ovarian syndrome transsexuality

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Gender identity disorder according DSM-IV-TR - Polycystic ovary syndrome (PCOS) with clinical or biochemical signs of hyperandrogenism - Eligible for hormone treatment

Exclusion criteria

Exclusion criteria: - Persons with insufficient command of the Dutch language - Unadjusted endocrine disorders - Current treatment with sex steroids - Neurological or psychiatric disorders that could lead to deviant test results - Neuropharmacological intervention - Alcohol (>5 units per day) or drug abuse - Contra indications for an MRI scan - Excessive androgen production other than the hypersecretion of androgens from the ovaries - Pregnancy (excluded by a pregnancy test) - Current desire to have children

Design outcomes

Primary

Measure	Time frame
• Blood oxygen level dependent (BOLD) response in functional MRI • Test results from the neuropsychological assessments	—

Secondary

Measure	Time frame
• Reproductive endocrine serum samples • Blood pressure • Anthropometric measurements • Depression score • Anxiety score	—

Countries

Netherlands

Outcome results