The rate of glucose uptake over the blood-brain barrier in humans in vivo, measured by 13C magnetic resonance spectroscopy

The rate of glucose uptake over the blood-brain barrier in humans in vivo, measured by 13C magnetic resonance spectroscopy - Glucose uptake in human brain

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON36330

Enrollment

Registered

2011-05-10

Start date

2011-06-13

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Diabetes Mellitus

Interventions

Administration of [1-13C] glucose Blood sampling through arterial line Insulin administration in patients

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All volunteers: age between 18-60 years;Patients with Type 1 Diabetes Mellitus: Stable glycaemic control with HbA1c 6.5-9.0% Duration of diabetes >5 years

Exclusion criteria

Exclusion criteria: All volunteers: History of epilepsia or operations of the brain Metal implants or pace-maker;Patients: All complications of Diabetes except background retinopathy Hypoglycemia unawareness Medication other then oral anti-conceptiva or thyroxine supplements

Design outcomes

Primary

Measure	Time frame
• the time difference between the cerebral 13C glucose peak and the blood glucose peak after intravenous glucose loading	—

Secondary

Measure	Time frame
• areas under the cerebral 13C glucose and blood glucose response curve • times until 13C glucose and blood glucose have returned to baseline values	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)