high blood pressure hypertension
Conditions
Interventions
All patients will be treated with spironolactone, triamterene and placebo for a
2-week period. During the whole study, all subjects will continue their own
antihypertensive drugs as described earlie
Sponsors
Maasstadziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: -age 18 years and older -on hemodialysis at least 3 months before inclusion -daily diuresis less than 500 mL -predialysis serum potassium
Exclusion criteria
Exclusion criteria: -myocardial infarction, stroke or transient ischaemic attack less than 6 months before inclusion -angina pectoris -heart failure -hypotension (predialysis systolic blood pressure below 100 mmHg) or severe hypertension (predialysis SBP>180 mmHg and/or DBP>100 mmHg) -pregnancy -known allergy to study drugs -any acute illness requiring treatment -malignant disease -expected non-adherence to treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the change in predialysis systolic blood pressure during automatic blood pressure measurement after treatment with spironolactone and triamterene. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are changes in 24-hours blood pressure, neurohormonal profile, interdialysis weight gain, 24-hours sodium excretion, and serum elektrolyte concentrations. | — |
Countries
Netherlands
Outcome results
None listed