Genetic Basis of Neuroticism-Related Brain Activation: A Genetic Imaging Study

Genetic Basis of Neuroticism-Related Brain Activation: A Genetic Imaging Study - Genetic Basis of Neuroticism-Related Brain Activation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36326

Enrollment

120

Registered

2011-03-01

Start date

2011-05-02

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

persoonlijkheidstrek emotional instability neuroticism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Female Age range: 18-25 years Caucasian descent Dutch as native language Right-handed;Additional criterion for the Trails adolescents only: Having a genotype that is under-represented in the initial student sample

Exclusion criteria

Exclusion criteria: presence of neurological or psychiatric disorders in present or past use of medication that can influence task results visual or hearing problems that cannot be corrected voor fMRI: MR incompatible implants in the body (such as ear prothesis or other metal implants) Any risk of having metal particles in the eye, due to manual work without proper eye protections Tattoos containing red pigments (Suspected) pregnancy Claustrophobia The refusal to be informed of structural brain abnormalities that could be detected during the experiment

Design outcomes

Primary

Measure	Time frame
The main study parameter concerns differences in neuroticism-related brain activation patterns (BOLD response) measured with functional magnetic resonance imaging (fMRI) in relation to genotype within different cognitive-emotional processing tasks, targeting emotional face processing, interoceptive sensitivity, emotional conflict and reward processing and worry. We are interested in the l/l, s/l and s/s genotypes of the SERT (5-HTTLPR) gene and the Met/Met (A/A), Val/Val (G/G) and Met/Val (A/G) genotypes of the COMT (rs4680, Val158Met) gene. In relation to the length polymorphism 5-HTTLPR, the SNP rs25531 will to be taken into account.	—

Measure

Time frame

The main study parameter concerns differences in neuroticism-related brain activation patterns (BOLD response) measured with functional magnetic resonance imaging (fMRI) in relation to genotype within different cognitive-emotional processing tasks, targeting emotional face processing, interoceptive sensitivity, emotional conflict and reward processing and worry. We are interested in the l/l, s/l and s/s genotypes of the SERT (5-HTTLPR) gene and the Met/Met (A/A), Val/Val (G/G) and Met/Val (A/G) genotypes of the COMT (rs4680, Val158Met) gene. In relation to the length polymorphism 5-HTTLPR, the SNP rs25531 will to be taken into account.

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Secondary

Measure	Time frame
Functional connectivity between brain regions	—

Countries

Netherlands

Outcome results