hypertensie pheochromocytoma
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male and female patients (all ages, including children above 5 yr) with suspected pheochromocytoma/paraganglioma if they fulfill one or more of the are following criteria: (i) patients with a previous history of PPGLs. (ii) new onset of hypertension or therapy-resistant hypertension or hypertensive episodes and/or symptoms suggestive of PPGLs. (iii) family history of PPGL or genetic mutations known to predispose individuals to develop PPGLs. (iv) presence of an accidently found adrenal tumor (v) any other reasonable clinical suspicion of a PPGL ;For establishing reference intervals the following patients will be enrolled: (i) treated or untreated male and female patients with primary hypertension (>140/90 mm Hg) (above 18 yr). (ii) healthy normotensive volunteers (above 18 yr)
Exclusion criteria
Exclusion criteria: • Patients with impaired mental capacity that precludes informed consent. • Subjects who need medications that may interfere with or invalidate outcome parameters (e.g., tricyclic antidepressants). • Pregnancy does not constitute criteria for exclusion from the protocol. However, in pregnant women no PET scanning, MIBG scanning or contrast CT will be performed. • Patients at risk from injury from the MRI magnet due to implantable metal or who suffer from anxiety in enclosed spaces are excluded from MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Numbers of true-positive, false-positive, true-negative and false-negative results of each biochemical test. • Biochemical, metabolic, molecular and secretory profiles as related to the clinical manifestations, malignant development and germline mutations. • Blood pressure profiles, cardiac function parameters and indices of disease progression. | — |
Countries
Netherlands
Outcome results
None listed