heart attack myocardial infarction
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Chest pain suggestive for myocardial ischemia for at least 30 minutes, - Electrocardiogram (ECG) with ST- segment shifts (ST-segment depression >1 mm in at least two contiguous leads or transient ST-segment elevation >1 mm with duration of 1.5 mm in at least three contiguous leads), - Positive troponin T >0,04 µg/L. - Time between the onset of last symptoms and PCI of more than 12 hours and shorter than 7 days, - initial conservative management (e.g. asprin, heparine, statins) - The presence of one ischemia-related target lesion on invasive coronary angiography with a clinical indication for PCI, - TIMI flow grade of 2 or higher, - Vessel suitable for 2.25 mm diameter or larger stent implantation, - Informed consent.
Exclusion criteria
Exclusion criteria: - Persistent ST-elevation of > 1 mm in 2 or more leads, - TIMI 0 or 1 flow on coronary angiography, - Need for emergency coronary artery bypass grafting, - Presence of cardiogenic shock, - Preexisting life-threatening disease with a life expectancy of less than 6 months, - Creatinine > 200 µmol/l before the procedure, - Inability to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of effective thrombus aspiration as determined by histopathological examination, the residual thrombus load on OCT after thrombus aspiration and stent implantation | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of angiographic parameters (thrombosis in myocardial infarction flow grade, myocardial blush grade, distal embolization), and clinical outcomes (death, myocardial infarction, target vessel revascularization 30 days after the procedure). | — |
Countries
Netherlands
Outcome results
None listed