auditory verbal hallucinations schizophrenia
Conditions
Interventions
None listed
Sponsors
Divisie Hersenen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers: - for experiment 1: between age 18-40yr. - for experiment 2: matched with available patient group with respect to age (18-65yr), gender and education;Patients: - between age 18-65yr - diagnosed with schizophrenia according to DSM IV will be included. - able to lie in an MRI scanner and prevent head movements for a short period of time (about 15 minutes)
Exclusion criteria
Exclusion criteria: The following list of exclusion criteria is for both controls and patients, unless noted. - non-removable metal objects in head/body - pregnancy - history of closed- or open head injury - history of psychiatric illness (healthy controls only) - history of neurological illness or endocrinological dysfunction - history of epilepsy - occurrence of epilepsy in 1st degree family - use of medication other than anticonceptive or paracetamol (healthy controls only) - drug or alcohol abuse over a period of six months prior to the experiment - intake of alcohol, caffeine or nicotine containing products within 4 hrs prior to the scanning sessions. - claustrofobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters for experiment 1 are functional brain networks evoked with TMS. Such a network consists of maps of induced percent signal change in BOLD MR images over the entire brain. In experiment 2 the main outcome is the difference in percent signal change between patients and controls along connections in the language network. See also chapter 5 of the protocol text. | — |
Countries
Netherlands
Outcome results
None listed