The role of endometrial angiogenesis in patients with bleeding disorders in case of submucous fibroids

The role of endometrial angiogenesis in patients with bleeding disorders in case of submucous fibroids - Endometrial Angiogenesis related to fibroids.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36239

Enrollment

Registered

2011-08-02

Start date

2012-02-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fibroid leiomyomata

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Premenopausal women, aged above18 years, with a regular menstrual cycle planned for a transcervical hysteroscopic resection (TCRM) of submucous fibroids.

Exclusion criteria

Exclusion criteria: Occlusion or embolization of uterine arteries in the history, risk of pelvic inflammatory disease, known endometrioses, cervical cancer or pregnancy.

Design outcomes

Primary

Measure	Time frame
Differences in histological vascular density (based on CD34/31) in endometrium covering fibroids versus normal endometrium.	—

Secondary

Measure	Time frame
Differenes in kwantified VEGF-A, VEGF-B, VEGF-C, FGF, Estradiol receptor, Progesterone receptor expression, kwantified hysteroscopic vascular density (using Narrow Band Imaging). Level of CD34/31 related ki67 expression. The relation between endometrial vascularity index and angiogenic profile in endometrium covering a fibroid with severity of menstrual bleeding (PBAC) and total number of days will be assessed. Potential prognostic parameters: age, cycle day, OC or GnRHa use, fibroid size and level of protrusion (GIS) and vascular indices measured with 3D TV-US will be registered.	—

Measure

Time frame

Differenes in kwantified VEGF-A, VEGF-B, VEGF-C, FGF, Estradiol receptor, Progesterone receptor expression, kwantified hysteroscopic vascular density (using Narrow Band Imaging). Level of CD34/31 related ki67 expression. The relation between endometrial vascularity index and angiogenic profile in endometrium covering a fibroid with severity of menstrual bleeding (PBAC) and total number of days will be assessed. Potential prognostic parameters: age, cycle day, OC or GnRHa use, fibroid size and level of protrusion (GIS) and vascular indices measured with 3D TV-US will be registered.

—

Countries

Netherlands

Outcome results