gastroesophageal reflux disease (GERD) heartburn
Conditions
Interventions
None listed
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers: Written informed consent Age 18-65 years Patients with Barrett*s esophagus: Written informed consent Age 18-65 years A circular Barrett segment confirmed by histopathology
Exclusion criteria
Exclusion criteria: GERD Surgery of the GI-tract other than appendectomy Gastro-intestinal complaints Medication influencing acid secretion or GI motility. Participation in another study with exposure to radiation within the last year patients: Participation in another study with exposure to radiation within the last year inability to stop with PPI for 1 week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pepsin concentration and activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Trypsin concentration and activity pH, density, viscosity | — |
Countries
Netherlands