Skeletal Muscle Metabolism during Rest, Exercise and Recovery in Patients with Cystic Fibrosis and Healthy Controls

Skeletal Muscle Metabolism during Rest, Exercise and Recovery in Patients with Cystic Fibrosis and Healthy Controls - Muscle Metabolism in CF

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36204

Enrollment

Registered

2011-05-13

Start date

2011-08-31

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mucoviscidosis

Interventions

None listed

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: Patients with CF: - Ambulant patients with CF - free from acute pulmonary or gastro-intestinal exacerbation - from 12 to 18 years Healthy controls: - from 12 to 18 years - free from constraints in performing a maximal exercise test

Exclusion criteria

Exclusion criteria: Patients with CF: - Resting oxygen saturation (SpO2)

Design outcomes

Primary

Measure	Time frame
- * time of PCr recovery (31P MRS) - Resting, exercise and recovery phoscreatine (PCr)(31P MRS) - Resting, exercise and recovery Inorganic phosphorus (Pi)(31P MRS) - Resting, exercise and recovery Pi:PCr ratio(31P MRS) - Resting, exercise and recovery (Adenosine triphosphate) ATP(31P MRS) - Resting, exercise and recovery ATP:PCr ratio(31P MRS)Change in concentration deoxygenated hemoglobin. (NIRS) - Change in concentration oxygenated hemoglobin. (NIRS) - Change in concentration total hemoglobin. (NIRS) - Change in concentration deoxygenated hemoglobin minus change in concentration oxygenated hemoglobin. (NIRS) - The T1/2 (s) change in oxygenated hemoglobin in the recovery phase. (NIRS)	—

Measure

Time frame

- * time of PCr recovery (31P MRS) - Resting, exercise and recovery phoscreatine (PCr)(31P MRS) - Resting, exercise and recovery Inorganic phosphorus (Pi)(31P MRS) - Resting, exercise and recovery Pi:PCr ratio(31P MRS) - Resting, exercise and recovery (Adenosine triphosphate) ATP(31P MRS) - Resting, exercise and recovery ATP:PCr ratio(31P MRS)Change in concentration deoxygenated hemoglobin. (NIRS) - Change in concentration oxygenated hemoglobin. (NIRS) - Change in concentration total hemoglobin. (NIRS) - Change in concentration deoxygenated hemoglobin minus change in concentration oxygenated hemoglobin. (NIRS) - The T1/2 (s) change in oxygenated hemoglobin in the recovery phase. (NIRS)

—

Secondary

Measure	Time frame
- Peak workload (Wpeak) - Resting and peak oxygen uptake (VO2peak/kg (ml.min-1.kg-1) ) - Resting and peak minute ventilation (VEpeak) (l.min-1) - Resting and peak respiratory exchange ratio (RER = VCO2/VO2) - Resting and peak heart rate (HR; bpm) - Resting and peak SpO2	—

Countries

Netherlands

Outcome results