bipolar disorder depression mood disorders
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All MDD and BD I and BD II patients of both sexes: age 18-60 years; at least 2 MDEs, with remission between episodes; age of first episode * 40 years; illness duration of * 5 years since the first episode. Non-depressed MDD and BD patients: no diagnosis of major depressieve episode (MDE) at time of baseline (according to SCID) In addition, for BD: at least one manic episode (assessed by SCID) not solely during the use of antidepressants. Healthy controls: age 18-60 years; euthymia at time of baseline (According to SCID; Inventory for Depressive Symptoms (IDS) *14)
Exclusion criteria
Exclusion criteria: MDD and BD I / II patients: electroconvulsive therapy within 2 months before scanning; current (hypo)mania (Young Mania Rating Scale (YMRS) > 8; at study entry or within the previous month before baseline); a current depressive episode according to the SCID or a HDRS>16; atypical depressive symptomatology; concurrent co-morbid Axis I diagnosis; a clear clinical diagnosis of cluster B personality disorder (assessed by previous documentation and/or a history of recurrent suicidal and parasuicidal acts); currently using psychopharmacological medication (antidepressants, anticonvulsants or mood-stabilizers stopped *1 month before scanning). Incidental benzodiazepine use will be allowed, but must be stopped before scanning. In addition, for MDD: a history of (hypo)manic derailment after antidepressant use; a family history of bipolar disorder. HC: a lifetime psychiatric diagnosis (axis I, assessed by SCID); a current diagnosis of alcohol or drug dependence; first-degree relatives with a history of a psychiatric diagnosis; use of any psychopharmacological agent. All subjects: a history of head trauma or neurological disease; severe general physical illness; claustrophobia or implanted metal objects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We will compare performance on the exogenous curing task between MDD, BD and HC, measured by response time, number of omissions and number of errors. The same outcome will be examined for the neuroimaging tasks. We will compare brain responses of fMRI tasks relative to control conditions between MDD, BD and HC. We will compare responses in predefined ventral and dorsal brain regions (dorsolateral prefontal cortex (PFC) ventral PFC, orbitofrontal, limbic and subcortical regions). | — |
Countries
Netherlands
Outcome results
None listed