vaccinatierespons er wordt geen aandoening bestudeerd nvt
Conditions
Interventions
There are three invervention groups that have to take paracertamol for 24 hours
(1000 mg / 8h). Timing of the paracetamol use is different: group 1 will take
paracetamol at the time of vaccination (
Sponsors
RIVM
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Good health. - Able to perform the study according to the procedures. - Informed consent present.
Exclusion criteria
Exclusion criteria: - History of acute or chronic hepatitis B - Earlier hepatitis B vaccination - Evidence of a serious disease, that needs immunosuppresive treatment. - A known primary or secondary immunodeficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antibody concentrations prior to and 1 month after the third vaccination (booster vaccination) will be measured. Antibody concentrations expected to be lower in participants that used paracetamol prophylactically. The titers in the groups treated therapeutically with paracetamol cannot be predicted and are subject of this study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Alterations in the functionality of specific lymfocyte subpopulations in blood of participants that used paracetamol prophylactically. | — |
Countries
Netherlands
Outcome results
None listed