The role of filaggrin loss-of-function mutations in skin barrier and inflammatory response

The role of filaggrin loss-of-function mutations in skin barrier and inflammatory response - Filaggrin gene mutations and skin barrier

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36165

Enrollment

Registered

2012-11-20

Start date

2011-03-01

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irritant contact dermatitis + Atopic dermatitis / Hand eczema + atopic eczema

Interventions

On three consecutive days, volunteers will be dermally exposed for 4 hours to 0.25% and 0.5% SLS on both volar forearms using exposure chambers of 18 mm Ø. On one forearm, before applying SLS, skin

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Caucasian Age between 18 - 55 years

Exclusion criteria

Exclusion criteria: Visible dermatitis on the forearms Systemic inflammatory disease or skin diseases other than AD Sunbathing or using a tanning bed during 2 months prior to the investigation Use of antihistaminics or inflammation suppressing medicines (e.g. corticosteroids, NSAIDs) or antibiotics three months prior to, or during the investigation.

Design outcomes

Primary

Measure	Time frame
1. Changes in transepidermal water loss (TEWL), pH and erythema 2. Levels of filaggrin degradation products and cytokines in the stratum corneum harvested by using adhesive tape 3. Skin morphology as assessed by using confocal laser scanning microscopy (Vivascope, MAVIG, Germany)	—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)