Glycocalyx in cerebral small vessel disease

Glycocalyx in cerebral small vessel disease - Glycocalyx in cerebral small vessel disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36152

Enrollment

Registered

2011-08-29

Start date

2012-03-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral small vessel disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: patients: first-ever lacunar stroke in the last 2 years, age 50-85 years healthy controls: age 50-85 years, without major co-mobidity

Exclusion criteria

Exclusion criteria: patients: carotid stenosis, cardioembolic source, diabetes, coronary heart disease, major co-morbidity healthy controls: hypertension, diabetes, cardiovascular disease (TIA/stroke/coronary heart disease), use of cardiovascular medicine, silent signs of cSVD on (former) brain MRI

Design outcomes

Primary

Measure	Time frame
Registration of baseline characteristics (age, gender, weight, length, medication, cardiovascular risk profile, brain MRI) Venous blood sampling for measuring of glucose, cholesterol, kreatinin, and CRP. Measurement of the sublingual glycocalyx, non-invasively using sidestream dark field imaging. We will compare glycocalyx thickness between patients and controls, and between patients with and without silent lesions. Predictors of glycocalyx thickness will be analysed using regression analyses.	—

Measure

Time frame

Registration of baseline characteristics (age, gender, weight, length, medication, cardiovascular risk profile, brain MRI) Venous blood sampling for measuring of glucose, cholesterol, kreatinin, and CRP. Measurement of the sublingual glycocalyx, non-invasively using sidestream dark field imaging. We will compare glycocalyx thickness between patients and controls, and between patients with and without silent lesions. Predictors of glycocalyx thickness will be analysed using regression analyses.

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Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results