Geheugenproblemen nvt
Conditions
Interventions
Participants will be treated with roflumilast 100 *g, roflumilast 300 *g,
roflumilast 1000 *g,or a placebo. All treatments will be taken orally. The
treatment order will be established by counterbal
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Male or female, 18 to 35 years of age, healthy (i.e. absence of all exclusion criteria), normal static binocular acuity (corrected or uncorrected), body mass index between 18.5 and 30, willingness to sign an informed consent, positive evaluation on the medical and memory screening
Exclusion criteria
Exclusion criteria: Volunteers who suffer from, or have a history of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological, or psychiatric illness, will be excluded. Other exclusion criteria are excessive drinking (>20 glasses of alcohol containing beverages a week), pregnancy or lactation, use of chronic medication other than oral contraceptives, use of recreational drugs from 2 weeks before until the end of the experiment, smoking, ortostatic hypotension, lactose intolerance, and any sensory or motor deficits which could reasonably be expected to affect test performance. Those volunteers who have a first-degree relative with a psychiatric disorder or a history of depressive disorder with or without suicidal risk will be excluded as well.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Other important measures are the Stroop task and continuous performance taak (CPT-AX). In addition, the event-related potentials during those tasks will be analysed. Moreover, the ratio (S2/S1) of the P50 is a measure of sensory gating. | — |
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the behavioural score on the memory tests; the verbal learning task (VLT) and the object relocation task (ORT). | — |
Countries
Netherlands
Outcome results
None listed