The influence of Vitamin B12 deficiency on the expression of Leber Hereditary Optic Neuropathy (LHON)

The influence of Vitamin B12 deficiency on the expression of Leber Hereditary Optic Neuropathy (LHON) - LHON and vitamin B12 deficiency

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36113

Enrollment

Registered

2011-10-28

Start date

2012-06-25

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

genetic disease of the optic nerve Leber Hereditary Optic

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: LHON patients: -clinical characteristics of LHON -proven LHON mutation - recent loss of vision (not longer then half a year);Control patients: - same gender as LHON patient for which will be matched - same age (+/- 3 years) as LHON patient for which will be matched (but not younger then 18 years)

Exclusion criteria

Exclusion criteria: LHON patient - younger then 18 years;Control patients -known optic neuropathy -actual treatment by medical specialist (except ophthalmologist) - known bowel disease, for which patient receives treatment - actual neurological disease, for which patient is under treatment - known renal dysfunction - known diabetes mellitus - known thyroid disease - known anemia - veganistic diet - excess alcohol intake (> 4 units a day) -pregnancy - medication: gastric acid secretion inhibitors, colchicine - smoking

Design outcomes

Primary

Measure	Time frame
Prevalence of a vitamin B12 deficiency in the LHON and control population.	—

Secondary

Measure	Time frame
Cause of vitamin B12 deficiency in the LHON patients	—

Countries

Netherlands

Outcome results