allergic rhinitis hay fever
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with allergic rhinitis -Age 18-35 years -No severe co-morbidity, other than allergic symptoms -Proven allergic rhinitis (based on clinical evaluation of a medical doctor or with positive RAST) experiencing at least nasal symptoms -Suffering from outdoor allergies (hay fever, pollen, weeds, grass) or indoor allergies (mold, dust, dust mite) or pet allergies. - Good understanding of the Dutch language - Willingness to receive a member of the investigation team in the house of the participant;Controls -Healthy individuals 18-35 years with a runny nose
Exclusion criteria
Exclusion criteria: -Any severe comorbidity -Any other infection during the department visit -Immunological nasal disease (Churg-Strauss syndrome, Sjögren*s syndrome, systemic lupus erythematosus, sarcoidosis, Wegener*s granulomatosis) -Use of nasal corticosteroid spray 1 month or less prior during the hospital visit. -Use of oral corticosteroids 1 month or less prior during the hospital visit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) Expression of inhibitory receptors (LAIR-1, SIRL-1, CD200R, CTLA-4 en SIRP-a) on leukocytes in peripheral blood and nasopharyngeal washes (2) Changes in inhibitory receptor expression in nasopharyngeal washes during the course of disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| -Flow cytometry of will be used to study inhibitory receptor expression during the course of disease | — |
Countries
Netherlands
Outcome results
None listed