Cardiac function and volume status during liver transplantation

Cardiac function and volume status during liver transplantation - Cardiac function and volume status during liver transplantation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36089

Enrollment

Registered

2011-09-22

Start date

2012-02-29

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

levertransplantaties liver transplantation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients scheduled for LTx

Exclusion criteria

Exclusion criteria: Allergy for substances used during LTx Cardiovascular instability as judged by anesthesiologist Respiratory insufficiency as judged by anesthesiologist

Design outcomes

Primary

Measure	Time frame
To measure cardiac strain and strain rate during liver transplantation by speckle tracking The outcome of speckle tracking is a dimensionless number called strain and describes the amount of deformation in these myocardial markers when a stress is induced. With TEE four-chamber images will be acquired with a GE Vivid 7 ultrasound machine (GE Medical Systems, Horten, Norway) in B-Mode and digitally stored on a hard disc. To obtain an adequate resolution for off-line analysis frame rate will be set to a minimal of 45 framesminute-1. The off-line software of EchoPAC Dimension 06 (GE Medical Systems, Horten, Norway) will be installed on a workstation for the application of Speckle Tracking.	—

Measure

Time frame

To measure cardiac strain and strain rate during liver transplantation by speckle tracking The outcome of speckle tracking is a dimensionless number called strain and describes the amount of deformation in these myocardial markers when a stress is induced. With TEE four-chamber images will be acquired with a GE Vivid 7 ultrasound machine (GE Medical Systems, Horten, Norway) in B-Mode and digitally stored on a hard disc. To obtain an adequate resolution for off-line analysis frame rate will be set to a minimal of 45 frames*minute-1. The off-line software of EchoPAC Dimension *06 (GE Medical Systems, Horten, Norway) will be installed on a workstation for the application of Speckle Tracking.

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Secondary

Measure	Time frame
To evaluate the effect of major fluid changes (anhepatic phase, reperfusion, massive blood loss) on cardiovascular parameters determined by invasive and less invasive techniques. To evaluate the effect of major fluid changes (anhepatic phase, reperfusion, massive blood loss) on pharmacokinetics and pharmacodynamics of midazolam and alfentanil. To evaluate hepatic functional capacity with ICG plasma disappearance rate and near-infrared fluorescence measurements	—

Measure

Time frame

To evaluate the effect of major fluid changes (anhepatic phase, reperfusion, massive blood loss) on cardiovascular parameters determined by invasive and less invasive techniques. To evaluate the effect of major fluid changes (anhepatic phase, reperfusion, massive blood loss) on pharmacokinetics and pharmacodynamics of midazolam and alfentanil. To evaluate hepatic functional capacity with ICG plasma disappearance rate and near-infrared fluorescence measurements

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Countries

Netherlands

Outcome results