Mapping the galactosemic brain: Finding the neural correlates of language impairments

Mapping the galactosemic brain: Finding the neural correlates of language impairments - Mapping the speaking galactosemic brain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON36086

Enrollment

Registered

2011-06-13

Start date

2012-01-13

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Classic galactosemia

Interventions

None listed

Eligibility

Age

12 Years to 99 Years

Inclusion criteria

Inclusion criteria: A diagnosis of classic galactosemia as assessed by GALT enzyme activity assay or GALT-gene mutation analysis (information obtained from treating physician) Age between 14 and 20 years old

Exclusion criteria

Exclusion criteria: Any other disorder or disease that could affect cognitive functioning independently of classic galactosemia (an exception is made for the diagnosis of Attention-Deficit/Hyperactivity Disorder (ADHD), because this disorder is common in this group)

Design outcomes

Primary

Measure	Time frame
The main parameters are measures derived from 1) structural MRI scans (i.e. lesions in white matter, cortical thickness), 2) functional MRI during a language task and during rest (i.e. % of BOLD change in selected regions of interest; ROIs, Granger causality correlations), 3) DTI (i.e. fractional anisotropy; FA, and mean diffusity; MD, and DTI tractography), 4) the behavioral paradigm (i.e. number of errors, voice onset latencies).	—

Measure

Time frame

The main parameters are measures derived from 1) structural MRI scans (i.e. lesions in white matter, cortical thickness), 2) functional MRI during a language task and during rest (i.e. % of BOLD change in selected regions of interest; ROIs, Granger causality correlations), 3) DTI (i.e. fractional anisotropy; FA, and mean diffusity; MD, and DTI tractography), 4) the behavioral paradigm (i.e. number of errors, voice onset latencies).

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Secondary

Measure	Time frame
These contain the more general measures that will be used to obtain more information about the participants. In the analyses, these parameters will be used descriptively, as covariate or in a correlation analysis: - Speech therapy treatment, physical therapy or special education - Relevant medical history - Comorbidity ADHD - Metabolic information, such as GALT mutation, GALT enzyme activity, urine galactose and galactitol - Nutrition parameters, such as soy, vitamin and trace elements intake	—

Measure

Time frame

These contain the more general measures that will be used to obtain more information about the participants. In the analyses, these parameters will be used descriptively, as covariate or in a correlation analysis: - Speech therapy treatment, physical therapy or special education - Relevant medical history - Comorbidity ADHD - Metabolic information, such as GALT mutation, GALT enzyme activity, urine galactose and galactitol - Nutrition parameters, such as soy, vitamin and trace elements intake

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Countries

Netherlands

Outcome results