A clinical study to investigate the effects of remote ischemic preconditioning on cardiac mitochondrial hexokinase in CABG patients

A clinical study to investigate the effects of remote ischemic preconditioning on cardiac mitochondrial hexokinase in CABG patients - mtHK after RIPC in CABG patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON36080

Enrollment

Registered

2011-05-20

Start date

2012-03-05

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular disease - heart disease

Interventions

The RIPC protocol exists of 3*5 minutes of limb ischemia, induced by blood pressure cuff inflation of the left upper arm. The first group will receive this treatment after induction of anaesthesia,

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients who have to undergo first time elective on-pump CABG without valve surgery - older than 18 years

Exclusion criteria

Exclusion criteria: - Diabetes or representing with hyperglycaemia (glucose > 8mM) - increased preoperative cardiac troponin T values - Unstable angina or angina within 48 hours before infarction - Concomitant procedures - Ejection fraction

Design outcomes

Primary

Measure	Time frame
Main study parameters are the HK mitochondrial binding ratio and cardioprotection, evaluated by plasma cardiac troponin T (cTnT) values.	—

Secondary

Measure	Time frame
Secondary parameters are cytokine (IL-6, IL-10 and TNF-a) levels and inotropic score. Furthermore CRP will be determined at the same time points as cTnT.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)