hyperthermie (inspanningsgerelateerd) hyperthermia
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age : 18-45 years • Willing to sign informed consent • Healthy
Exclusion criteria
Exclusion criteria: - hypersensitivity or idiosyncratic reaction to paracetamol. - pregnant or lactating women. - hepatic and/or renal impairment from participation. - Because of potential interaction with other medication, we will exclude subjects with cholestyramine (which reduced the absorption speed of paracetamol), metoclopramide or domperidone (which speed of absorption of paracetamol is increased), warfarin (increased risk of bleeding) or chloramphenicol (increased plasma levels of chloramphenicol). - obstructive disease of the gastro-intestinal tract (including diverticulitis and inflammatory bowel disease or previous gastrointestinal surgery, except cholecystectomy and appendectomy) - subjects that will undergo a MRI-scan within 2 days after one of the testing days - subjects with a cardiac pacemaker or other implanted electromedical devices - As subjects will be performing a submaximal cycling test, we will also exclude: • Hypertension (systolic blood pressure > 140 mmHg or diastolic blood pressure > 90 mmHg) • Any cardiovascular abnormality in past medical history, physical examination or ECG, including prolonged QTc interval. • BMI>=30 kg/m2 • Inability to perform bicycle exercise • The presence of an absolute or relative contra-indication for exercise testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Core body temperature (continuous) 2. Plasma levels of pyrogens (IL-1, IL-6, TNF en IFNg) | — |
Countries
Netherlands
Outcome results
None listed