hepatitis C
Conditions
Interventions
A. OME 40 mg QD for 5 consecutive days (OME alone)
B. BOC 800 mg TID for 4 consecutive days + a single dose of 800 mg on Day 5
(BOC alone)
C. OME 40 mg QD for 5 consecutive days combined with BOC 800
Sponsors
Universitair Medisch Centrum Sint Radboud
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Subject is at least 18 and not older than 55 years at screening. 2. Subject des not smoke more than 10 cigarettes, 2 cigars, or 2 pipes per day for at least 3 months prior to the first dosing 3. Subject has a Quetelet Index (Body Mass Index) of 18 to 30 kg/m2, extremes included. 4. Subject is able and willing to sign the Informed Consent Form prior to screening evaluations. 5. Subject is in good age-appropriate health condition as estab-lished by medical history, physical examination, electrocardi-ography, results of biochemistry, haematology and urinalysis testing within 4 weeks prior to Day 1. Results of biochemistry, haematology and urinalysis testing should be within the laboratory's reference ranges. If laboratory results are not within the reference ranges, the subject is included on condition that the Investigator judges that the deviations are not clinically relevant. This should be clearly recorded. 6. Subject has a normal blood pressure and pulse rate, according to the Investigator's judgement.
Exclusion criteria
Exclusion criteria: 1. Documented history of sensitivity/idiosyncrasy to medicinal products or excipients. 2. Positive HIV test. 3. Positive hepatitis B or C test. 4. Pregnant female (as confirmed by an HCG test performed less than 4 weeks before Day 1) or breast-feeding female. Female subjects of childbearing potential without adequate contraception, e.g. hysterectomy, bilateral tubal ligation, (non-hormonal) intrauterine device, total abstinence, double barrier methods, or two years post-menopausal. They must agree to take precautions in order to prevent a pregnancy throughout the entire conduct of the trial. 5. Therapy with any drug (for two weeks preceding dosing), except for paracetamol. 6. Relevant history or presence of pulmonary disorders (especially COPD), cardiovascular disorders, neurological disorders (especially seizures and migraine), psychiatric disorders, gastro-intestinal disorders, renal and hepatic disorders, hormonal dis-orders (especially diabetes mellitus), coagulation disorders. 7. Relevant history or current condition that might interfere with drug absorption, distribution, metabolism or excretion. 8. History of or current abuse of drugs, alcohol or solvents. 9. Inability to understand the nature and extent of the trial and the procedures required. 10. Participation in a drug trial within 60 days prior to the first dose. 11. Donation of blood within 60 days prior to the first dose. 12. Febrile illness within 3 days before Day 1.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the effect of multiple dose OME on the pharmacokinetics (AUC0-8h, Cmax, C8h) of BOC. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the effect of steady state BOC on the pharmacokinetics (AUC0-8h, Cmax, C8h) of multiple dose OME. To study the safety of steady state BOC combined with multiple dose OME. | — |
Countries
Netherlands
Outcome results
None listed